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The binding of the substrate induces a conformational change at the TMDs. This change in turn retransmits to the NBDs, changing its conformation and indirectly inducing the initiating of ATP hydrolysis. So we can see that both NBDs and TMDs must be present for the hydrolysis of ATP (Higgins, 2001). The hydrolysis of ATP induces further conformational change at the NBDs, the effect is passed on to TMDs which reverses to its original shape(Higgins, 2001). These steps mark the cyclical process of active transport.
An experiment conducted by Bishop and his associates demonstrated that ATP is indeed the source of energy used by transport proteins for the active transport of molecules across the membrane...
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Common topics in this essay:
- Title : Transport across membrane
- transport
- Cell Membrane/ Electron Transport Chain / Biochemical Pathway
- History Of Cell Membrane
- ATP as a Source of Energy for Periplasmic Permease in the Membrane Transport Systems
- Biological Transport
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- Plasma Membrane
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- The Cell Membrane
- The Importance of Membrane Transport
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