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The deviousness of the disease defies almost all attempts at discovering a cure. Asthma can be mild; it can be devastating. Sometimes the symptoms disappear for many years but surface again with even greater severity.
In an asthmatic attack the diameter of the small bronchi is diminished as a result of spasm of the muscular coat, active congestion of the mucous membrane and excessive secretion of tough mucus. In inspiration the small bronchi are pulled open and the obstruction is thereby reduced. On the other hand, forced expiration tends to compress bronchi and increase the obstruction. Consequently inspiration is much easier than expiration; the difficult breathing of asthma differs in fact from all other forms of difficult breathing, in being mainly expiratory in character (Mezei, 1988)...
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