Asthma

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Title: Asthma

Essay Details:

Subject: Science

Author: Sophie R

Date: April 25, 2015

Level: University

Grade: A

Length: 2 / 373

Essay text:

Bronchiodilators are a class of drug that relaxes airway smooth muscle by increasing cAMP and opening potassium channels. Corticosteriods on the other hand are now considered the first line of treatment for patients with severe and chronic asthma. Corticosteriods bind to a receptor in the cytosol, which translocates to the nucleus and binds DNA to activate genes. The main action of corticosteriods is to suppress multiple inflammatory genes, such as cytokines, inflammatory enzymes and adhesion molecules. The effectiveness of the corticosteriod is in most part due to the inhibition of transcription factors, such as AP-1 (activation protein 1), Nuclear factor-?b (NF-?b), and nuclear factor of activated T-cells (NF-AT), which are required for inflammatory response...

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