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With all the recent information, one might well ask “Is there a place for aprotinin in current practice?”
A plethora of negative publicity has followed the publication in January 26, 2006 of an article in the New England Journal of Medicine. In a somewhat striking publication, it was accompanied by a wealth of venomous publicity in the lay press [1]. Additionally, legal websites touted for business. Mangano, using data collected from 1996 – 2000 (The McSPI EPI II database) reported an association of aprotinin use with an increase in mortality, renal dysfunction and MI after cardiac surgery...
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