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They also are a rich source of thromboxane A2. It is their activation that, in part, initiates the vascular phase of the acute inflammatory response (see Fig. 2-13 in text). To have them play this role makes imminently good sense, because they are present in large numbers throughout the circulation, i.e., some are always in close proximity to an inciting stimulus.
Vasoactive Literally translated, this adjective means that a substance has the capacity to alter the physiologic state, especially the tone and caliber, of a vessel.
Platelet-Derived Growth Factor (PDGF), a dimeric glycoprotein composed of two A and/or B chains, is the principal mitogen in serum for mesenchymal cells...
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