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Once advanced the sufferer may require a caretaker as daily
chores become very difficult to accomplish. Evidence points toward amyloid as
one of the main causes for the occurring cytotoxic processes. Researchers have
found that degeneration appears to be caused by interference with intracellular
calcium homeostasis via activation of calcium channels, intracellular calcium
stores, and further production of free radicals by calcium-sensitive enzymes.
The glutamatergic system seems to be involved in mediating the toxic processes.
In the brain, the nerve cells in the part that controls memory and thinking are
damaged, this interrupts the passage of messages between communicating cells...
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