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However, as is discussed, the degree of AQP2 downregulation as well as the intracellular localization of the protein differs significantly among the various conditions, suggesting that different mechanisms are responsible for AQP2 dysregulation in the various models. In addition to DI, a few other serious conditions are associated with reduced AQP2 levels and urinary concentrating defects (see Table 2).
1. Lithium-induced NDI
Lithium administration is a very common treatment of manic-depressive disease. It is estimated that 1 in 1,000 of the population receive lithium, and roughly 20-30% of these develop serious side effects including polyuria (16, 39) primarily due to a vasopressin-resistant urinary-concentrating defect, i...
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