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As the inflammatory process progresses, the synovial cells and subsynovial tissues undergo reactive hyperplasia. This causes vasodilatation and increased blood flow to the affected joint causing warmth and redness. The result of the increased capillary permeability that accompanies the inflammatory process is the joint swelling that occurs. An extensive network of new blood vessels develop in the synovial membrane which contributes to the advancement of the disease. This vascular tissue is called pannus which is a feature of RA that differentiates it from other forms of inflammatory arthritis” (p...
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