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During systole, blood is ejected from the left ventricle into the aorta. If the aortic semilunar valve is affected, some of the ejected blood flows back into the left ventricle. Volume overload occurs in the ventricle because it receives blood from the left atrium during diastole and blood from the aorta during systole. Over time the end diastolic volume of the left ventricle increases and myocardial fibers stretch to accommodate the extra fluid. Ventricular dilation and hypertrophy eventually cannot compensate for the aortic incompetence and heart failure develops. Clinical manifestations include widened pulse pressure resulting from increased stroke volume and back flow...
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