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A second limitation of previous research has been small subject groups, which may have affected the ability to detect associations with genes having small effects (16). In addition, previous research has relied on general assessments of smoking status (e.g., smokers versus nonsmokers). Given the complex nature of smoking behavior and its etiology, it is critical that the phenotypes for genetic studies of smoking be well defined (17). Finally, there has been a lack of attention to adolescent populations in research evaluating genetic contributions to smoking behavior. The genes involved in smoking experimentation and acquisition of a habit during adolescence may be different from those that maintain a smoking habit or explain nicotine dependence in adulthood...
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