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This "sickled cell," which resembles a crescent moon, can't continue to glide through the small blood vessels as usual. Instead, it gets stuck in the tiny blood vessels, blocking the flow of blood and causing pain.
The spleen, an organ on the left side of the abdomen across from the liver, is responsible for filtering the blood for infections and other abnormalities. Normal red blood cells can change shape and squeeze through this filter, but sickled cells get stuck and cannot recirculate through the body, so that the number of circulating blood cells goes down. Meanwhile, the bone marrow, where red blood cells are made, pitches in by making more cells...
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