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Oola is affecting his neurotransmitters by the daily use of marijuana. Marijuana works as an agonist, it blocks the receptor site, and the neurotransmitters cannot get across the synapse.
Sean Astin’s character, Doug, is Lucy’s aggressive brother. This aggression can be attributed to his abuse of steroids. This steroid abuse may have affected Doug’s amygdala, the part of the limbic system that controls aggression and fear. Conversely, it may have affected Doug’s hypothalamus, which is also involved in aggression.
In conclusion, all the characters seem to have some type of brain dysfunction...
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