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LH acts on the Leydig cells in the testis, causing them to produce testosterone. FSH, together with testosterone act on the Sertoli cells in the testis to regulate the production and maturation of spermatozoa. Testosterone in turn acts on thehypothalamus and anterior pituitary to suppress the production of GnRH, FSHand LH, producing a negative-feedback mechanism which keeps everything well-regulated. The small amount produced in the adrenal (in both sexes) is regulated by secretion of adrenal corticotrophic hormone (ACTH), also secreted by the pituitary.
Testosterone, and its metabolites such as dihydrotestosterone, act in many parts of the body, producing the secondary sexual characteristics ofthen male: balding, facial and body hair, deep voice, greater muscle bulk,thicker skin, and genital maturity...
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