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POGs lead to changed cells or transformed cells and cause excessive cell division. Further mutations cause the cells to become immortal. These cells continue to divide and form a ball of cells. These cells require a lot of energy and fluids flowing to maintain the high rate of the cell division. When these balls become too large for fluids to flow through, the middle of the ball dies. TSG’s act as anti-proto-oncogenes, they regulate the rate of cell division. POG’s and TSG’s constantly compete to overpower each other. These TSG’s can be mutated and this brings about a change in the control mechanism of cell division...
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