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It is a member of the globin gene family, a group of genes involved in oxygen transport, and hemoglobin binds oxygen in the lungs and delivers it to the other tissues. Most people have two normal genes for hemoglobin. Some people carry one normal gene and one gene for sickle hemoglobin. This is called "sickle cell trait".
These people are normal in almost all respects. Problems from having a single sickle cell gene develop only under very unusual conditions. People who inherit two genes for sickle hemoglobin (one from each parent) have sickle cell disease. It is believed that individuals with African and Mediterranean ancestry have unusually high frequency of sickle cell trait due to the reduced mortality from malaria infections when compared with individuals who do not carry the hemoglobin variant
Red blood cells carrying the abnormal gene (hemoglobin S) travel normally through circulation until they are deoxygenated...
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