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Essay Details:
Essay text:
The inhibiting effect of the ritonavir on the CYP34A can be used to improve the pharmakinetic profile of the saquinavir.
Aim:
To check if patients with a lack of response to HAART with SQV-HGC, 600mg TID, can be rescued by changing the SQV-HGC for SQV-SGC/RTV, 1600/200mg once a day.
Methods:
Three consecutive patients with a lack of response (viral charge > 1000 copies/mL) to HAART with SQV-HGC were included. SQV-HGC was changed for SQV-SGC/RTV, 1600/200mg once a day, and at the same time, the same two analogues of nucleosids, at least until the week 3. At the basal moment after 3,12 and 24 weeks, some clinical, virological and biological evaluations were made, and the plasmatic trough and the peak levels of saquinavir were measured...
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