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Since SCID is also considered a recessive disorder, it is usually inherited from carrier mothers, unaffected females that contain one normal and one mutated copy of the gene. The son of a carrier has a 50 percent chance of inheriting the disorder while the daughter needs two mutant X chromosomes, thus the father would have to be affected and somehow have survived long enough in order to reproduce and pass on his mutated copy of the gene. Consequently, males tend to be affected by X-linked SCID much more frequently than females. (Griffiths, et al. pg 63, 64, 71, 72)
X-linked SCID is caused by a mutation in the IL2RG gene that encodes the Y-common chain...
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