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The observed decrease in oxygen concentration was proportional to glucose concentration. This is the first of many variations of the basic biosensor design that emerged out of Dr Clark's concept. Through the next several decades, the biosensor technology took off radically as a variety of new devices was discovered including enzymes, nucleic acids, and cell receptors. In looking at the historical development of this technology, 1980's was certainly the inventive decade, with commercialization being the theme in the 1990's.
Biosensors' primary functions in terms of research and commercial applications are identifying target molecules, identifying the availability of a suitable biological recognition element, and the potential for disposable detection systems to replace sensitive lab techniques...
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