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Most diuretics share the same basic mechanism of action: they block sodium and chloride reabsorption. The greatest diuresis is produced by those drugs whose site of action is early in the nephron.
4. Adverse effects caused by diuretics on the extracellular fluid include hypovolemia, acid-base imbalance, and disturbance of elytrolite levels.
5. The four major categories of diuretic drugs include loop diuretics, thiazide diuretics, osmotic diuretics, and potassium-sparing diuretics.
6. Situations that require rapid or massive mobilization of fluid are usually treated with furosemide.
7. The most widely used thiazide diuretic is hydorchlorothiazide, whose primary indication for use is hypertension...
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