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We don't really have a good understanding of the long-term effects in people because much of the "ecstasy" sold isn't really ecstasy. So when side effects are seen in users, we don't know if it is from ecstasy or another drug. The studies in animals, however, suggest that long-term use has the potential for causing learning and memory problems and psychiatric illnesses later in life. Ecstasy also appears to have an effect on the immune system.
No drug is free of unwanted side effects. No drug is completely safe. This is true of ecstasy, alcohol, nicotine, marijuana, over-the-counter and prescription drugs...
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