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There is no sex or breed disposition although there has some evidence suggesting a maternal link for calves of infected cows. The modal age at onset is -5 years and can span the commercial lifespan of the infected cattle. The pathogenesis of the disease is unknown, but studies indicate that that after oral ingestion of infected feed, the agent replicates in the Peyer's patches of the ileum followed by migration via the peripheral nerves to the Central Nervous System.
Initial clinical findings are subtle and are behavioral in nature. (8) Signs and symptoms of BSE in cattle include the following:
Affected cattle may display changes in temperament, such as nervousness or aggression;
? Abnormal posture;
? Poor coordination and difficulty in rising;
? Decreased milk production;
? Loss of body condition despite continued appetite;
? The incubation period ranges from 2 to 8 years;
? There is no treatment, and affected cattle die;
? Death generally occurs within 6 months of onset of the disease...
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