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Most of the mutations result in a miss-formed protein product; thus the nature of these mutations is easily interpreted. Two successive acquired mutations occurring in a single cell are necessary for the development of cancer. Mutations anywhere along either gene are associated with an increased risk for breast cancer. (Transmed Network-Breast Cancer-Characteristics of Hereditary Breast Cancer, 1997).
More than six hundred different mutations have been identified on the BRCA1 gene. (Gene Clinics, 2000). The number of mutations found on the BRCA1 gene is different than those found on the BRCA 2 gene...
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