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Low doses of Provera have shown to bind to the receptors in the brain and block GnRH production. There are certain disorders that children can develop- when their GnRH is not released into the brain. For instance, gonadotropin-independent precocity, this is when the Childs ovaries or testes still make steroids even without the release of GnRH.
Since these children are still producing steroids without GnRH being released, low doses of Provera are not effective. For the body to produce steroid hormones it must convert cholesterol into estrogens and other related substances. In order for this process to take place, several steps are involved which are controlled by a certain enzyme...
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