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Skeletal muscle fibers arise from a hundred or more small mesodermal cells called myoblasts. The mature skeletal muscle fiber has a hundred or more nuclei. Once fusion occurs the skeletal muscle fiber will lose the ability to undergo cell division. This means that the number of muscle fibers is set before birth and most of these fibers will last a lifetime.
The muscle growth that occurs after birth is a result of the enlargement of these existing muscle fibers. The mature muscle fibers have a few myoblasts, which remain as satellite cells. These myoblasts retain the capacity to join with one another or with damaged muscle fibers in order to regenerate these muscle fibers...
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