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The dose-dependent increase in heart rate ranges from 20-100% although varies largely between individuals, with a peak in heart rate occurring 20-30 minutes after smoking marijuana as noted by Roth et al. In addition most subjects will experience an increase in blood pressure when supine (lying down with face pointing upwards). Also as noted by Hollister, postural (standing straight up) hypotension is not uncommon, additionally frequent use may cause a resistance to the hemodynamic effects as noted by Benowitz. Apart from the hemodynamic effect, smoking marijuana results in an increase of carboxyhemoglobin, which results in a lowered oxygen carrying capacity of regular red blood cells...
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