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Not much is known in regards to how MRP-1 confers multidrug resistance, a notable exception is that its expression has been associated with a decrease in drug accumulation similar to P-glycoprotein [1]. Glutathione is an important cellular antioxidant and detoxification protein, and its increased levels have been observed to inactivate various chemotherapeutic drugs [2]. Bcl-2 is a known inhibitor of apoptosis and its cellular overexpression has been observed to increase resistance to drugs whose mechanism of action involve apoptotic initiation [2]. FasL (Fas ligand), upon binding, induces apoptosis in cells expressing Fas receptors...
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