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In the liver, the ammonia is quickly converted to urea, which is relatively nontoxic, and is then released into the bloodstream. In the blood, it is readily removed through the kidneys and excreted in the urine. Any disease or condition that reduces glomerular filtration or increases protein catabolism results in elevated BUN levels.
Creatinine is another indicator of kidney function. Creatinine is a waste product derived from creatine. It is freely filtered by the glomerulus and blood levels are useful for estimating glomerular filtration rate. Muscle tissue contains phosphocreatinine which is converted to creatinine by a nonenzymatic process...
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