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fMRI
? Used to monitor changes in blood flow and blood volume in the brain within a couple of hundred milliseconds, better spatial resolution than PET. fMRI offers poor selectivity, and requires a higher signal to noise ratio in order to get a good image. Whole brain areas as well as specific loci can be assessed and displayed within an anatomical framework. Also, non invasive
? Basic Principles of MR imaging
o Image?the disruption of hydrogen atoms in tissue
o There are difference in distribution of H+ atoms and magnetic properties of different tissues
o Differences also reveal changes in blood flow
o Based on different magnetic properties of oxygenated (arterial) and deoxygenated (venous) blood
o When subjected to certain gradient echo pulse sequences, oxygenated blood provides a stronger MR signal?the difference between hemoglobin in oxygenated vs deoxygenated blood provides the fMRI image
o Cognitive activation-vasodilation-where neurons are more active-oxygenated blood will exceed metabolic need
? +++Physics of fMRI Imaging
o Fixed magnetic field is generated
o varies from 0...
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