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Types of Human Genetic disorders
a. Human Chromosomal Abnormalities
1. Nondisjunction
? Occurs when homologous chromosomes fail to segregate during meiosis
? Produces gametes with three chromosome pairs (trisomy) or only one chromosome of a normal pair (monosomy)
? Involves any chromosomes, including the sex chromosomes
? Causes serious genetic disorders
Ex: Down's syndrome- trisomy 21
Edward's syndrome- trisomy 18
Patau syndrome- trisomy 13
2. Klinefelter's syndrome, XXY
? Results when an abnormal sperm, containing both X and Y-chromosomes, fertilizes a normal egg with one X-chromosome
? Can also result when an XX egg is fertilized by a Y sperm
? Offspring has genotype XXY
? Occurs in 1 in 1000 born males
? Have reduced fertility and maybe mentally retarded
3...
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