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In the book they use the example of Ignaz Semmelweis, he was a doctor in the mid-1800s in Austria who couldn’t figure out why so many patients in his ward were dying. He tried everything he could think of to change the situation. He set the standard regulations so that all the wards did everything the same way, still fatality rate in his ward was far higher than any other. Turns out that many of the doctors in his ward were doing research on dead bodies and then coming to examine live patients without washing their hands (hand washing and general hygiene things that we take for granted were not known of at this time)...
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