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"The basic idea is that, instead of having to plod through all the hundreds of ways you might get a protein to crystallize, you more or less try 'em all at once."
Schultz pioneered combinatorial methods as a member of the Lab's Materials Sciences Division; he recently became head of the Novartis Institute for Functional Genomics in La Jolla, California. He and his colleague Raymond Stevens of the Lab's Physical Biosciences Division saw the combinatorial approach as a natural solution to the challenge of growing protein crystals.
That's because "biologists really have no idea what the best conditions are for growing crystals of a new protein," says Derek Yegian, a member of the team that built the new robotic system...
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