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Many of these antigens are also present on normal tissue cells and so the antibodies against them could be harmful. In 1975 Kohler and Milstein found what first envisaged 80 years earlier. Since then a prodigious number of different monoclonal
antibodies have been made and they have been exploited in almost every
branch of biomedical research. Several have been found which recognise human
cancers and some of these have been tested in clinical trials. The first studies relied on the intrinsic ability of the antibody molecules to recruit the body?s own defence mechanisms to kill tumour cells. When these natural mechanisms were found to be insufficient, various artificial warheads were proposed including conventional chemical drugs, and plant toxins...
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